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Publications

22. Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse
H. C. W. McArthur, A. T. Bajur, M. Iliopoulou, and K. M. Spillane
Proc. Natl. Acad. Sci. USA 122, e2422528122 (2025)
21. Quantifying force-mediated antigen extraction in the B cell immune synapse using DNA-based tension sensors
H. C. W. McArthur*, A. T. Bajur*, and K. M. Spillane
Methods Cell Biol. 193, 229-252 (2025) (*equal contribution)
20. Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells
J. Obajdin*, D. Larcombe-Young*, M. Glover, F. Kausar, C. M. Hull, K. R. Flaherty, G. Tan, R. E. Beatson, P. Dunbar, R. Mazza, C. Bove, C. Taylor, A. Bille, K. M. Spillane, D. Cozzetto, A. Vigilante, A. Schurich, D. M. Davies, and J. Maher
Cell Rep. Med. 5, 101827 (2024) (*equal contribution)
19. Mechanical control of antigen detection and discrimination by T and B cell receptors
J. Rogers*, A. T. Bajur*, K. Salaita, and K. M. Spillane
Biophys. J. 123, 2234-2255 (2024) (*equal contribution)
18. Extracellular matrix rigidity modulates physical properties of SCS macrophage-B cell immune synapses

M. Iliopoulou, A. T. Bajur, H. C. W. McArthur, M. Gabai, C. Coyle, F. Ajao, R. Köchl, A. P. Cope, and K. M. Spillane

Biophys. J. 123, 2282-2300 (2024).

17. The role and regulation of the NKG2D/NKG2D ligand system in cancer

G. Tan, K. M. Spillane, and J. Maher

Biology 12, 1079 (2023).

16. Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

A. Martinez-Riano, S. Wang, S. Boeing, S. Minoughan, A. Casal, K. M. Spillane, B. Ludewig, and P. Tolar

Nat. Immunol. 24, 1281-1294 (2023).

15. Intrinsic properties of human germinal center B cells set antigen affinity thresholds

K. Kwak, N. Quizon, H. Sohn, A. Saniee, J. Manzella-Lapeira, P. Holla, J. Brzostowski, J. Lu, H. Xie, C. Xu, K. M. Spillane, P. Tolar, and S. K. Pierce

Sci. Immunol. 3, eaau6598 (2018).

14. Mechanics of antigen extraction in the B cell synapse

K. M. Spillane and P. Tolar

Mol. Immunol.101, 319-328 (2018).

13. Evidence for a vibrational phase-dependent isotope effect on the photochemistry of vision

C. Schnedermann, X. Yang, M. Liebel, K. M. Spillane, J. Lugtenburg, I. Fernández, A. Valentini, I. Schapiro, M. Olivucci, P. Kukura, and R. A. Mathies

Nat. Chem. 10, 449-455 (2018).

12. DNA-based probes for measuring mechanical forces in cell-cell contacts: Application to B cell antigen extraction from immune synapses

K. M. Spillane and P. Tolar

Methods Mol. Biol. 1707, 69-80 (2018).

11. Functionalisation of detonation nanodiamond for monodispersed, soluble DNA-nanodiamond conjugates using mixed silane bead-assisted sonication disintegration

R. Edgington, K. M. Spillane, G. Papageorgiou, W. Wray, H. Ishiwata, M. Labarca, S. Leal-Ortiz, G. Reid, M. Webb, J. Foord, N. Melosh, and A. T. Schaefer

Sci. Rep. 8, 728 (2018).

10. B cell antigen extraction is regulated by physical properties of antigen-presenting cells

K. M. Spillane and P. Tolar

J. Cell Biol. 216, 217-230 (2017).

9. Germinal center B cells recognize antigen through a specialized immune synapse architecture

C. R. Nowosad, K. M. Spillane, and P. Tolar

Nat. Immunol. 17, 870-877 (2016).

8. High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning

K. M. Spillane*, J. Ortega-Arroyo*, G. de Wit, C. Eggeling, H. Ewers, M. I. Wallace, and P. Kukura

Nano Lett. 14, 5390-5397 (2014). (*equal contribution)

7. Label-free, all-optical detection, imaging, and tracking of a single protein

J. Ortega-Arroyo, J. Andrecka, K. M. Spillane, N. Billington, Y. Takagi, J. R. Sellers, and P. Kukura

Nano Lett. 14, 2065-2070 (2014).

6. Wavepacket splitting and two‐pathway deactivation in the photoexcited visual pigment isorhodopsin

D. Polli, O. Weingart, D. Brida, E. Poli, M. Maiuri, K. M. Spillane, A. Bottoni, P. Kukura, R. A. Mathies, G. Cerullo, and M. Garavelli

Angew. Chem. Int. Ed. 53, 2504-2507 (2014).

5. Force generation in B-cell synapses: Mechanisms coupling B-cell receptor binding to antigen internalization and affinity discrimination

P. Tolar and K. M. Spillane

Adv. Immunol. 123, 69-100 (2014).

4. Direct observation and control of supported lipid bilayer formation with interferometric scattering microscopy

J. Andrecka, K. M. Spillane, J. Ortega-Arroyo, and P. Kukura

ACS Nano 7, 10662-10670 (2013).

3. Conformational homogeneity and excited-state isomerization dynamics of the bilin chromophore in phytochrome Cph1 from resonance Raman intensities

K. M. Spillane, J. Dasgupta, and R. A. Mathies

Biophys. J. 102, 709-717 (2012).

2. Conical intersection dynamics of the primary photoisomerization event in vision

D. Polli, P. Altoe, O. Weingart, K. M. Spillane, C. Manzoni, D. Brida, G. Tomasello, G. Orlandi, P. Kukura, R. A. Mathies, M. Garavelli, and G. Cerullo

Nature 467, 440-443 (2010).

1. Homogeneity of phytochrome Cph1 vibronic absorption revealed by resonance Raman intensity analysis

K. M. Spillane, J. Dasgupta, J. C. Lagarias, and R. A. Mathies

J. Am. Chem. Soc. 131, 13946-13948 (2009).

Email: k.spillane@imperial.ac.uk

Address:

Sir Alexander Fleming Building

Department of Life Sciences

Exhibition Road

London SW7 2AZ

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